|HSCI 540 - Radiation Biology
Information current as of 5:00 AM on February 25, 2018.
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Credit Hours: 3
Prerequisites: Prerequisite: HSCI 312, PHYS 220, 221; BIOL 110, 111; or Prerequisite: BIOL 415. Authorized equivalent courses or consent of instructor may be used in satisfying course pre- and co-requisites.
Syllabus: click here
Effects of ionizing radiation on living systems at the molecular, cellular and tissue levels. Biological basis for radiation therapy treatment planning and radiation protection.Instructor's description:
This three credit hour course provides an introduction to principles and concepts underlying the biological effects of ionizing radiation at the molecular, cellular and whole-tissue level. Topics covered include selected aspects of microdosimetry, radiation damage to DNA, DNA repair mechanisms, cell-cycle kinetics (repopulation effects), cell death mechanisms and clonogenic survival, Linear Energy Transfer (LET) effects and relative biological effectiveness (RBE), oxygen effects, apoptosis, acute effects of whole body irradiation, radiation carcinogenesis, hereditary effects of radiation, the tumor control probability (TCP), clinical responses of normal tissues to radiation, cancer biology, and biological indicators of treatment effectiveness, such as biologically equivalent dose (BED) and equivalent uniform dose (EUD) concepts. Examples and discussion related to radiation therapy treatment planning and radiation protection are covered. The course emphasizes critical thinking and problem solving skills over rote memorization.
Prerequisites: HSCI 312, BIOL 110 and 111 (or BIOL 415). Authorized equivalent courses or consent of instructor may be used in satisfying course pre- and co-requisites.